How to fix the Saving Issue
If you are experiencing difficulties when attempting to save a game in Wasteland 3, please check to see if you have any Anti-Virus security programs active. If so, make sure to allow Wasteland 3 to be recognized as a safe file.
If you have attempted to allow Wasteland 3 to be recognized but are still running into the issue, you may want to consider restarting your system, and opening your associated security program while as administrator. Please refer to the documentation for your security regarding the enabling of safe programs.
If you are unable to add Wasteland 3 as a safe program or are unsure if that has been successfully done, and are still running into the issue, consider temporarily disabling the ant-virus program and then run Wasteland 3 as Administrator to see if the issue persists.